The U.S. Department of Energy has signed memorandums of understanding with 24 organizations to collaborate on the Genesis Mission, a DOE-led effort to use AI to “accelerate discovery science, strengthen national security, and drive energy innovation.”

DOE tied the partnership slate to President Donald Trump’s Nov. 24 executive order launching the Genesis Mission and directing DOE to stand up an “American Science and Security Platform” that integrates national lab supercomputers, secure cloud-based AI environments, datasets, domain foundation models, and AI agents that can automate workflows and accelerate research.

The executive order directs DOE to submit a list of at least 20 national science and technology challenges within 60 days (due Jan. 23, 2026), review national lab capabilities for robotic laboratories within 240 days (due July 22, 2026), and seek an initial operating capability of the Platform for at least one challenge within 270 days (due Aug. 21, 2026), subject to appropriations.

It also requires a first annual report to the president within one year (due Nov. 24, 2026) covering platform status, user engagement, research outcomes, and public-private partnership results.

DOE said the organizations that have signed MOUs either responded to a DOE request for information or already have active projects with DOE and the national labs. DOE added that ‘any products produced for the Genesis Mission will be architecture-agnostic,’ a phrase it used to describe how partners may contribute cloud infrastructure, models, and specialized compute.

The Dec. 18 DOE list includes Microsoft, Google, Amazon Web Services, Oracle, NVIDIA, OpenAI, Anthropic, IBM, Intel, AMD, Dell, Hewlett Packard Enterprise, Palantir, xAI, and others.

On the company side, Google DeepMind said it will provide an “accelerated access program” for scientists across all 17 DOE National Laboratories to its “frontier AI for Science models and agentic tools,” starting with “AI co-scientist” on Google Cloud.

Anthropic said it will make Claude available to DOE researchers and provide a dedicated team to build purpose-built tools, including AI agents, Model Context Protocol servers, and Claude Skills tailored to lab workflows.

OpenAI said it signed an MOU with DOE to explore collaboration supporting DOE initiatives including the Genesis Mission under its OpenAI for Science effort, and described the MOU as a framework for information sharing and follow-on agreements as projects are defined.

NVIDIA said the MOU with DOE outlines collaboration priorities spanning areas such as open AI science models, robotics and “autonomous labs,” nuclear fission and fusion, and quantum computing research.

DOE is also funding early platform components. On Dec. 10, the department announced over $320 million in investments to build initial Genesis Mission capabilities, including the American Science Cloud, the Transformational AI Models Consortium, 14 robotics and automation projects, and 37 foundational AI awards aimed at validated models and AI-ready datasets for scientific applications.

DOE said it will continue accepting submissions to two open RFIs: “Partnerships for Transformational Artificial Intelligence Models” (open until Jan. 14, 2026) and “Transformational AI Capabilities for National Security” (open until Jan. 23, 2026).